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A FANDOM User
• 1/6/2017
0 1
• 7/30/2015

Helpful Hint: Gene Names vs. Mutations

Hey Mark2Curators!
I thought I'd post a piece of information here that might help everyone discern between gene names (highlight!) vs gene mutations (don't highlight) more quickly. In research papers the standard notation for a mutation in the DNA sequence or the protein sequence is to write it as "LETTER-POSITION NUMBER-LETTER", usually there are 2-3 numbers in the middle:
Ex. M694V, R408Q, A72E, P32Q, A566C
(What this is saying in the case of M694V is that there is a Valine amino acid (V) at position number 694 where there is usually a Methionine amino acid (M)) 
The best way to know if something is a gene name is to search for it in a gene name database, but if you also know what the mutation notation looks like you can rule out those abbreviations pretty quick!
Cheers, Skye
0 1
• 6/26/2015

Protein domains

When a doc gives the name of a specific domain or motif in a protein that is critical for function, should we highlight that along with the protein name? Since it could suggest a specific structure to search for in other proteins and therepies.
Ex. "EGF domain", "discoidin-like domain", "RGD motif"
0 1
A FANDOM User
• 5/30/2015

Collagen

Should I mark collagen?  (Quest2 - O-linked Glycosilation Disorders)

Mario
0 3
• 5/26/2015

Want to know more about Genes? Here are some fun resources to learn more!

Brief overview on what is DNA? What is a gene? https://www.youtube.com/watch?v=C8OL1MTbGpU (~2 min)
What is DNA? What are chromosomes? Good video explanation here: https://www.youtube.com/watch?v=8kK2zwjRV0M (10-12 min)
How are genes related to proteins? Good video explanation here: https://www.youtube.com/watch?v=itsb2SqR-R0 (10-12 min)
What is an allele, and how is it related to genes? https://www.youtube.com/watch?v=CBezq1fFUEA (10-12 min)
What is glycosylation and why is it important? https://www.youtube.com/watch?v=u38LjCOvDZU (4 min)
Anyone else have enjoyable learning resources they'd like to share?
0 0
A FANDOM User
• 5/18/2015

Human and not-human genes

Should we mark only human genes or also not human genes (for instance for quest 197:  shoud we mark only TMEM165 or also tmem165)?I think could be significant to put this indication in Genes Concept Marking Rules.CiaoMario
0 1
A FANDOM User
• 5/18/2015

mark gene mutations?

point mutation (T571G)amino acid substitution (F142V)homozygous for the A33V mutationALG6 allele bearing the A333V mutation
Should only ALG6 be marked in the situations above?
0 1
A FANDOM User
• 5/18/2015

transferrin - it's a protein, not a gene - right?

I almost always see that others have marked transferrin as a gene. I thought that because transferrin is a protein, that it should not be marked as a gene. Am I wrong?
0 2
A FANDOM User
• 5/16/2015

Metabolites Genes?

I've noticed that there are often biomolecules such as oligosaccharides, or amino acids that aren't genes or protein products of genes, but often occupy the same space linguistically in these articles.  Since there is no 'biomolecule' category, should these be categorized under the gene concept?
0 1
A FANDOM User
• 5/14/2015

Conserved oligomeric Golgi (COG) complex

Should we mark (of course  in green) the phrase "Conserved oligomeric Golgi (COG) complex"?
If not, what about the complex subunits (see quest  #162 and many other quests)?
Ciao
Mario
0 3